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==Di 09:00 Basic science - (tubuläre) Kinasen und Phosphatasen== ===SGK1, Membrantransport und Hypertonie=== [http://nephrologie.conference2web.com/users/7579 Lang-F] ähnlicher Vortrag des gleichen Redners: '''SG-Kinasen und Natriumtransport''' {{tp|p=25967121|t=2015. Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl- Cotransporter |pdf=http://jasn.asnjournals.org/content/early/2015/05/12/ASN.2014070728.full.pdf+html|usr=}} ??? nm 2011 7 1304 izocori ??? jasn 2015 inzelle / tarash {{tp|p=24526686|t=2014. Annexin A2 mediates apical trafficking of renal Na(+)-K(+)-2Cl(-) cotransporter |pdf=http://www.jbc.org/content/289/14/9983.full.pdf|usr=}} {{tp|p=23393317|t=2013. SPAK differentially mediates vasopressin effects on sodium cotransporters |pdf=http://jasn.asnjournals.org/content/24/3/407.full.pdf|usr=}} ===Lessons from monogenic forms of hypertension=== [http://nephrologie.conference2web.com/users/7679 Hadchouel-J] {{tp|p=11498583|t=2001. Human hypertension caused by mutations in WNK kinases |pdf=http://www.sciencemag.org/content/293/5532/1107.full.pdf|usr=}} {{tp|p=25113964|t=2014. WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4 |pdf=http://hyper.ahajournals.org/content/64/5/1047.full.pdf|usr=}} {{tp|p=24803536|t=2014. Chloride sensing by WNK1 involves inhibition of autophosphorylation |pdf=http://stke.sciencemag.org/content/sigtrans/7/324/ra41.full.pdf|usr=}} {{tp|p=25542968|t=2015. The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride |pdf=http://jasn.asnjournals.org/content/26/8/1781.long|usr=}} {{tp|p=25071208|t=2014. KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1) |pdf=http://www.pnas.org/content/111/32/11864.full.pdf|usr=}} {{tp|p=25834074|t=2015. KCNJ10 (Kir4 1) is expressed in the basolateral membrane of the cortical thick ascending limb |pdf=http://ajprenal.physiology.org/content/308/11/F1288|usr=}} {{tp|p=26319417|t=2015. Vasopressin-induced stimulation of the Na-activated K channels is responsible for maintaining the basolateral K conductance of the thick ascending limb (TAL) in EAST/SeSAME syndrome |pdf=http://www.sciencedirect.com/science/article/pii/S0925443915002604|usr=}} {{tp|p=25565204|t=2015. Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride |pdf=http://www.sciencedirect.com/science/article/pii/S1550413114005579|usr=}} {{utp|p=19194658|t=2009. Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization |pdf=http://link.springer.com/article/10.1007/s00018-009-8712-7|usr=}} ???bj 2013 ohto ??? {{tp|p=23453970|t=2013. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension |pdf=http://www.cell.com/cell-reports/pdf/S2211-1247(13)00100-9.pdf|usr=}} Louis-dit-Picard 2016 submitted, evtl cell-rep ???cell-metab 2013 pilham??? ===Die Serin-Threonin-Kinase LKB1 reguliert die Hippo Signalkaskade und spielt eine differentielle Rolle bei der Zystenbildung.=== [http://nephrologie.conference2web.com/users/7680 Viau-A] {{utp|p=17205356|t=2007. Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1) |pdf=http://link.springer.com/article/10.1007/s00424-006-0168-0|usr=}} {{tp|p=20075061|t=2010. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1 |pdf=http://jasn.asnjournals.org/content/21/3/489.full.pdf|usr=}} {{tp|p=20972424|t=2010. Primary cilia regulate mTORC1 activity and cell size through Lkb1 |pdf=http://sm.kidney.de/epmc.php?ep=eu&pmid=20972424&pmc=3390256&ti=Primary%20cilia%20regulate%20mTORC1%20activity%20and%20cell%20size%20through%20Lkb1|usr=}} {{tp|p=21138973|t=2011. Hippo signaling: growth control and beyond |pdf=http://dev.biologists.org/content/138/1/9.full.pdf|usr=}} {{tp|p=24362629|t=2014. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway |pdf=http://sm.kidney.de/epmc.php?ep=eu&pmid=24362629&pmc=4159053&ti=A%20genetic%20screen%20identifies%20an%20LKB1-MARK%20signalling%20axis%20controlling%20the%20Hippo-YAP%20pathway|usr=}} ===Zusammenspiel von WNK/SPAK/OSR1 Kinasen und Calcineurin im distalen Nephron=== [http://nephrologie.conference2web.com/users/7678 Mutig-K] ???c... 1991 (1999) Waldeyer {{tp|p=10884438|t=2000. Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy |pdf=http://www.pnas.org/content/97/14/8157.full.pdf|usr=}} {{tp|p=25415435|t=2015. mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity |pdf=http://www.jci.org/articles/view/73935/pdf|usr=}} {{tp|p=26163195|t=2015. Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway |pdf=http://ndt.oxfordjournals.org/content/early/2015/07/09/ndt.gfv270.long|usr=}} {{tp|p=11509829|t=2001. Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis |pdf=http://www.karger.com/Article/Abstract/51935|usr=}} ??? nejm 2002 setiawan {{tp|p=12417564|t=2002. Impaired renal Na(+) retention in the sgk1-knockout mouse |pdf=http://www.jci.org/articles/view/15696/pdf|usr=}} {{tp|p=15590995|t=2005. Role of Sgk1 in salt and potassium homeostasis |pdf=http://ajpregu.physiology.org/content/ajpregu/288/1/R4.full.pdf|usr=}} {{tp|p=16014448|t=2005. SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess |pdf=http://ajpregu.physiology.org/content/ajpregu/289/2/R395.full.pdf|usr=}} {{tp|p=16284089|t=2006. Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1 |pdf=http://ajpregu.physiology.org/content/ajpregu/290/4/R935.full.pdf|usr=}} {{tp|p=12215463|t=2002. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure |pdf=http://hyper.ahajournals.org/content/40/3/256.full.pdf|usr=}} {{tp|p=18753797|t=2008. Role of serum- and glucocorticoid-inducible kinase SGK1 in glucocorticoid regulation of renal electrolyte excretion and blood pressure |pdf=http://www.karger.com/Article/Abstract/151666|usr=}} {{tp|p=16924469|t=2006. Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1 |pdf=http://link.springer.com/article/10.1007/s00109-006-0082-0|usr=}} ???a... cellphysiolbiochem 2011 amjphysiol-x 2002 huang, paßt nichts vom kontext {{tp|p=18367651|t=2008. Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet |pdf=http://ajpregu.physiology.org/content/ajpregu/294/6/R2008.full.pdf|usr=}} ???dietz or 2004 ??? {{tp|p=16537821|t=2006. Renal function of gene-targeted mice lacking both SGK1 and SGK3 |pdf=http://ajpregu.physiology.org/content/ajpregu/290/4/R945.full.pdf|usr=}} ???palmedes jnlunklar 2006??? ???buini jnlunklar 2006??? {{tp|p=18209482|t=2008. Association of SGK1 gene polymorphisms with type 2 diabetes |pdf=http://www.karger.com/Article/Pdf/113757|usr=}} ???cr 2006 görlach {{tp|p=22031864|t=2012. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes |pdf=http://www.bloodjournal.org/content/bloodjournal/119/1/251.full.pdf|usr=}} ???fj 2012 eylenstein??? {{tp|p=25614279|t=2015. Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis |pdf=http://atvb.ahajournals.org/content/35/3/547.full.pdf+html|usr=}}

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