Velcalcetide
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{{mmst|Velcalcetide|Etelcalcetide+OR+{AMG_416}+OR+{KAI_4169}+OR+{ONO_5163}+OR+Telcalcetide+OR+Velcalcetide}} | {{mmst|Velcalcetide|Etelcalcetide+OR+{AMG_416}+OR+{KAI_4169}+OR+{ONO_5163}+OR+Telcalcetide+OR+Velcalcetide}} | ||
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| + | Velcalcetide, a novel calcimimetic, is an allosteric activator of casr, the calcium sensitizing receptor and is in development to treat secondary hyperparathyreoidism of chronical renal failure in a way similar to cinacalcet. | ||
==Mechanism of action== | ==Mechanism of action== | ||
Revision as of 06:15, 1 September 2015
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Moremed Velcalcetide Etelcalcetide+OR+{AMG_416}+OR+{KAI_4169}+OR+{ONO_5163}+OR+Telcalcetide+OR+Velcalcetide
Velcalcetide, a novel calcimimetic, is an allosteric activator of casr, the calcium sensitizing receptor and is in development to treat secondary hyperparathyreoidism of chronical renal failure in a way similar to cinacalcet.
Mechanism of action
| Journal article, free access |
| GET Velcalcetide for secondary hyperparathyroidism – first line [[expm{{{p}}}| Extract]] PDF directcontrib: goo |
| Journal article, free access |
| GET Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action Extract PDF direct |
| Journal article, free access |
| GET Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients Extract [ PDF direct] |
| Journal article, free access |
| GET Comparison of AMG 416 and cinacalcet in rodent models of uremia Extract PDF direct |
| Journal article, free access |
| GET Velcalcetide (AMG 416), a novel peptide agonist of the calcium-sensing receptor, reduces serum parathyroid hormone and FGF23 levels in healthy male subjects Extract PDF direct |
| Journal article, free access |
| GET AMG 416 (velcalcetide) is a novel peptide for the treatment of secondary hyperparathyroidism in a single-dose study in hemodialysis patients Extract [ PDF direct] |
Mentioned in Fulltext
| Journal article, free access |
| GET The use of fibroblast growth factor 23 testing in patients with kidney disease Extract PDF direct |
| Journal article, free access |
| GET Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis Extract PDF direct |
| Journal article, free access |
| GET Calcimimetics and outcomes in CKD Extract PDF direct |
Trials
