COVID19 Magnesium

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* (7) [http://www.moremed.org/SiteSearch.php?S1=%28mgso4+OR+magnesium+OR+hypomagnesemia+OR+hypomagnesiemia%29&S2=autophagy+OR+autophagic&S3=apoptosis+OR+apoptotic+OR+efferocytosis&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025 pubmed magnesium autophagy]
 
* (7) [http://www.moremed.org/SiteSearch.php?S1=%28mgso4+OR+magnesium+OR+hypomagnesemia+OR+hypomagnesiemia%29&S2=autophagy+OR+autophagic&S3=apoptosis+OR+apoptotic+OR+efferocytosis&submit=submit&px1=proxy.nationallizenzen.de&px2=&px3=&px4=&R=all&Y0=1500&Y1=2025 pubmed magnesium autophagy]
  
* (1050 items) [http://www.kidney.de/write/PMCmedVIP_c19_div01.html selected from (1)...(7) by title]
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* (1050 items) [http://www.kidney.de/write/PMCmedVIP_c19_div01.html selected from (1)...(7) by title] (top 450 items from this) [http://www.kidney.de/write/PMCmedVIP_C19_div01_subXX.html here]

Revision as of 09:46, 6 April 2020

I, incidentally, found a paper which described the actions of magnesium on macrophages, nfkb and inflammatory cytokines , after someone noted the small communication on hypercytokinemia in aggressive covid19 courses. Hydrochloroquine made me interested in macrophages so i grabbed the papers on Mphi in Influenza as a deeper investigated model subject to gain basic biological understanding since viruses & lungs are quite away from my subject area nephrology. All threads taken together I would like to arrive at the conclusion:

  • (1) put all mankind or all 60plus population on prophylactic oral magnesium supplementation to reach slightly supernormal mg2+ electrolyte levels
  • (2) give all intermediate care subjects mgso4 intravenously and apply nebulized mgso4 topically.
  • (3) measure mg2+ and ferritin at clinics entry level for post-hoc/ registry analyses
  • (4) do any supportive or experimental add-ons as clinically needed and use magnesium as a low-hazard entry-level starting medication.

Covid19 and its following congeners will target mankind for generations not for years. This-years generation has the responsibility to check even the cheapest interventions and prophylaxes.

It is early to shout out an idea but it takes time to read the literature as to give a valid academic explanation. Facts will be added on this page as I get them.

  • In the influenza papers there are some which make it inappropriate to eliminate the macrophages (remain to be read). This in mind.
  • Magnesium, DNase, NETosis might be a topic.


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